Chemical Safety


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The Office of Biosafety oversees chemical safety as well. This program includes chemical storage, use and disposal. Please refer to the following documents for assistance in proper chemical compatibility and storage. Included as well is the Ansell 7th Edition Glove Chemical Resistance Guide as a reference. Please be sure to check your glove manufacturer’s compatibility information before selecting gloves for any task to ensure they properly protect you from exposure. The Office of Biosafety will perform laboratory inspections on an annual basis for all Scott & White Healthcare research laboratories.

Chemical Hygiene Plan

In accordance wtih OSHA standards, the Office of Biosafety has developed a Chemical Hygiene Plan and Hazard Communication program. Information on either of these can be found in the current version of the Chemical Hygiene Plan PDF Document. The Chemical Hygiene Plan includes information on applicable OSHA standards, information on risks of exposures to hazardous chemicals, personal protective equipment and control measures, standard operating procedures for the use, handling, storage and disposal of chemicals, and emergency response procedures.

If you have chemical waste to dispose of, contact our office Send an e-mail with the name of the chemcial(s), the amount, the location and an emergency contact person and phone number. Be sure to review Section 6.4 of the Chemical Hygiene Plan for information on storage until pick-up.

Global Harmonization System

The Global Harmonization System of Classification and Labeling of Chemicals (GHS) is a system for standardizing and harmonizing the classification and labeling of chemicals across the world. Although regulations and laws are already in place in many countries, they are different enough to require multiple labels and safety data sheets for the same chemical both within the U.S. and in international trade. The GHS is not a regulation, but a guideline by which countries can develop a comprehensive national program to ensure the safe use of chemicals. The purpose of GHS is consistent hazard communication of pertinent information on the hazards and handling of chemicals, so employers, employees and the public can take preventive and protective measures for their health and safety. There is no specific timeline for the GHS, but many groups have already initiated use of the new system. If you would like more information, please refer to the SCHC-OSHA GHS Information Sheet PDF Document, OSHA Guide to the GHS, and UNECE Full GHS text.

Hazardous Chemical Use Review

If you are planning on using any hazardous chemicals that meet the requirements below, you must contact the Office of Biosafety prior to purchasing or using any of these chemcials. Certain procedures must be in place to ensure safe work practices are performed.

Chemical Safety Notice of Intent (NOI) Requirements:

A chemical is administered (via IP, IV, food, water, etc.) to a research animal for experimental purposes.
The chemical has - or is expected to have - one or more of the following characteristics listed in the table below:


Hazard Criteria Examples
Acetyl Cholinesterase Inhibitors All Parathion, Physostigmine, Diisopropylfluorosphate
Carcinogens Regulated by OSHA carcinogen Benzidine, Ethyleneimine
Listed by NTP as a Part A or Part B carcinogen Cyclophospamide, Tamoxifen, Doxorubicin, HCI, ENU, MNU, PCBs, Streptozotocin
Listed by IARC as a Group I, 2A, or 2B carcinogen Nickel compunds, Dimethyl sulfate, Etoposide (VP-16), Urethane
Other known carcinogens Azoxymethane
Chemotherapeutics All Busulfin, Cisplatin, Paclitaxel, Erlotinib, Fludara, Sutent, Pentostatin
Highly regulated chemicals RCRA P-listed chemicals Heptachlor, Physostigmine
RCRA U-listed chemicals DDT, ENU, MNU, Streptozotocin
RCRA D-listed chemicals Cadmium, Chromium, Lead, Mercury
EPA PIC Banned or severely restricted pesticides DDT, Aldrin, Dieldrin, Heptachlor
Severe environmental hazards PCBs
Irritants (cause a severe reversible inflammatory effect at the site of contact) Strong Irritants 5-FU, Phosgene
Irreversible Illness All MPTP, Thalidomide
Mutagens Known or suspected to cause mutations in humans BRDU
Known to cause mutations in animals Bleomycin Sulfate
Sensitizers (can cause an allergic reaction after repeated exposure) All Paclitaxel, Malathion, Isocyanates, Nickel Salts
Teratogens Known or suspected to cause teratogenic effects in humans 486, Thalidomide
Known to cause teratogenic effects in animals Bleomycin Sulfate, Erlotinib, Fludara
Toxics and Toxins LD50 (oral, rat) <500mg/kg Tetrodotoxin, picrotoxin, 5-FU, Rotenone, Chloropyrifos, DMBA
LD50 (dermal, rat) <1,000mg/kg Aldrin, Chloropyrifos, Dieldrin
LC50 (rat) <200 pm Acrolein, Diisopropylfluorophosphates, Dimethyl Sulfate, Parathion, Phosgene
Acute or chronic organ toxicity Potassium Cyanide, PCBs, Nickel Sulfide

Standard Operating Procedures

Standard Operating Procedures (SOPs) are used to ensure consistent safe handling and use of hazardous chemicals. The Office of Biosafety will provide SOPs to research personnel for hazardous chemicals that may require more specific handling and PPE measures to protect workers from exposure. All research personnel will be required to follow the Office of Biosafety’s SOPs when working with these chemicals. If you are working with a hazardous chemical  and are unsure of proper handling or if more specific safety measures are needed, please feel free to contact us for assistance. 

Streptozotocin SOP Document PDF Document

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